UPB
Upstream Bio, Inc. · Healthcare · Market cap $290.8M
Insiders sold $28K net in the last 90 days ·5 sellers, 0 buyers· latest Form 4 filed Sep 17, 2026
Insider Buying
$0
reported purchases (SEC code P)
Insider Selling
$105K
reported sales (SEC code S)
Unique Insiders
5
in the rolling window
Latest filing
Sep 17, 2026
Houghton Adam
Upstream Bio, Inc. (UPB) has 20 SEC Form 4 filings (20 transaction rows) in the rolling window, disclosed by 5 distinct insiders. Most recent filing: Sep 17, 2026.
Inside the rolling window, 5 insiders at Upstream Bio, Inc. reported no open-market purchases and 15 open-market sales totaling $105K. The most active filer is Chief Business Officer Houghton Adam with 3 filings. The most recent open-market filing is a sale of 700 shares by Chief Business Officer Houghton Adam, dated Sep 16, 2026, worth $4K.
- Industry:Biotechnology
- CEO:E. Rand Sutherland
- Employees:75
- HQ:Waltham, MA, US
- IPO:2024-10-11
| Source | |||||||
|---|---|---|---|---|---|---|---|
Houghton AdamFirst in 3 months | Chief Business Officer | Sale | 700 | $4K | Sep 17 | — | SEC ↗ |
GRAY MICHAELFirst in 3 months | CFO and COO | Sale | 853 | $5K | Sep 17 | — | SEC ↗ |
Ambrose AllisonFirst in 3 months | General Counsel | Sale | 485 | $3K | Sep 17 | — | SEC ↗ |
Sutherland Everett RandFirst in 3 months | Chief Executive Officer | Sale | 2,095 | $12K | Sep 17 | — | SEC ↗ |
Deykin AaronFirst in 3 months | Chief Medical Officer | Sale | 895 | $5K | Sep 17 | — | SEC ↗ |
Ambrose AllisonFirst in 3 months | General Counsel | Sale | 477 | $3K | Jun 17 | -13.7% | SEC ↗ |
Houghton AdamFirst in 3 months | Chief Business Officer | Sale | 700 | $4K | Jun 17 | -13.7% | SEC ↗ |
GRAY MICHAELFirst in 3 months | CFO and COO | Sale | 853 | $5K | Jun 17 | -13.7% | SEC ↗ |
Deykin AaronFirst in 3 months | Chief Medical Officer | Sale | 895 | $5K | Jun 17 | -13.7% | SEC ↗ |
Sutherland Everett RandFirst in 3 months | Chief Executive Officer | Sale | 2,095 | $13K | Jun 17 | -13.7% | SEC ↗ |
GRAY MICHAELFirst filing | CFO and COO | Sale | 852 | $8K | Mar 17 | — | SEC ↗ |
Deykin AaronFirst filing | Chief Medical Officer | Sale | 894 | $8K | Mar 17 | — | SEC ↗ |
Ambrose AllisonFirst filing | General Counsel | Sale | 475 | $4K | Mar 17 | — | SEC ↗ |
Houghton AdamFirst filing | Chief Business Officer | Sale | 699 | $6K | Mar 17 | — | SEC ↗ |
Sutherland Everett RandFirst filing | Chief Executive Officer | Sale | 2,093 | $19K | Mar 17 | — | SEC ↗ |
Earnings: last 7 quarters
Frequently asked questions
How many SEC Form 4 insider filings does UPB have?
Upstream Bio, Inc. (UPB) has 20 SEC Form 4 filings (20 transaction rows) in the rolling 365-day window, disclosed by 5 distinct insiders. Most recent filing: Sep 17, 2026.
When was the most recent SEC Form 4 filing for UPB?
The most recent Form 4 filing for UPB on Tracefour is dated Sep 17, 2026.
Who is the most active insider at UPB?
The most active SEC Form 4 filer at UPB in the rolling window is Chief Business Officer Houghton Adam, with 3 filings.
What is the net insider flow at UPB over the last 6 months?
Over the trailing 180 days, insiders at UPB have net sold $58K based on SEC Form 4 disclosures.
What is the total insider buy and sell value at UPB in the current window?
Inside the rolling window, insiders at UPB bought $0 and sold $105K based on SEC Form 4 filings.
Can I get alerts for UPB insider trading?
Yes. Tracefour sends a free email when a new SEC Form 4 purchase or sale is filed at Upstream Bio, Inc. (UPB). Alerts are set per company from the page itself, there is no paid tier, and each email links to the original filing on SEC EDGAR.
Related companies
Upstream Bio, Inc. is in the Healthcare sector.